I-Recombinant Human Thrombopoietin (rhTPO) imele ukuphumelela okukhulu ekulawulweni kokwelashwa kwezinkinga ezihlobene ne-thrombocytopenia. Njengendlela eyenziwe ngobuchwepheshe ye-hormone yemvelo i-thrombopoietin, i-rhTPO igqugquzela ukukhiqizwa kwamaplatelet, ixazulula ukushoda okubalulekile kwamaplatelet. Lo mbhalo unikeza ukubuka okujulile ku-rhTPO, okuhlanganisa izindlela zayo, izinkomba, izinzuzo, kanye nephrofayela yokuphepha, kugxilwe ekuthonyeni kwayo okuguqulayo ekunakekelweni kweziguli.

I-Thrombocytopenia yisimo sezokwelapha esibonakala ngokuba nenani eliphansi kakhulu lama-platelet egazini, okuholela ezingozini ezinkulu zokopha nokubambezeleka kokujiya kwegazi. Izimbangela ze-thrombocytopenia ziyahlukahluka, kusukela ekucindezelweni komnkala okubangelwa i-chemotherapy kuya ekubhujisweni okubangelwa amasosha omzimba njengoba kubonakala ku-Primary Immune Thrombocytopenia (ITP). Ukuqonda lezi zimbangela kubalulekile ekukhetheni amasu afanele okwelapha njenge-rhTPO therapy.

I-Chemotherapy ivame ukubangela i-myelosuppression, okuholela ekunciphisweni kokukhiqizwa kwama-platelet kanye ne-thrombocytopenia elandelayo. I-Recombinant Human Thrombopoietin ibonakale isebenza kahle ekunciphiseni lesi simo ngokukhuthaza ukwanda nokuhlukahluka kwama-megakaryocyte, okubuyisela amanani ama-platelet. Le ndlela yokwelapha inciphisa izinkinga zokuopha futhi isekela ukuqhubeka kwezinhlelo ze-chemotherapy ngaphandle kokuncishiswa kwemithamo.

Ngaphandle kokusetshenziswa okuhlobene ne-chemotherapy, i-rhTPO isebenza njengokwelashwa okungeziwe kwabantu abane-Primary Immune Thrombocytopenia, ikakhulukazi labo abanenani lamaplatelet elingaphansi kuka-20×10⁹/L abangaphenduli emitholeni ejwayelekile okubandakanya ama-corticosteroids. Ngokuthuthukisa ukukhiqizwa kwamaplatelet, i-rhTPO ithuthukisa i-hemostasis futhi yehlisa ubungozi bokopha ezigulini ezingapheli nezihlala njalo ze-ITP, zinikeza ithemba kubantu abangaphenduli ekwelashweni okujwayelekile.

I-rhTPO isebenza ngokubopha ku-thrombopoietin receptor (c-Mpl) kumangqamuzana esendlalelo lamathambo kanye namangqamuzana akhiqiza ama-megakaryocyte, okubangela ukwanda kwawo nokuvuthwa kwawo. Lokhu kudala ukwanda kokukhiqizwa kwamaplatelet nokukhululwa kwawo egazini. Ukuba yi-recombinant kwe-rhTPO kuqinisekisa umsebenzi wezinto eziphilayo ofana ne-endogenous thrombopoietin, okwenza ukuthi ukwelashwa kube nempumelelo nokuphepha.

Izifundo zezokwelapha zibonise ukuthi ukwelashwa nge-rhTPO kwandisa kakhulu inani lamaplatelet ezigulini ezine-thrombocytopenia ezivela ezimbangela ezahlukene. Izinzuzo zihlanganisa ukuqala okusheshayo komsebenzi, ukululama okuzinzile kwamaplatelet, kanye nokuncipha kwesidingo sokudluliselwa kwamaplatelet. Le miphumela iholela ekuthuthukisweni kwekhwalithi yokuphila kanye nokuncipha kwezinkinga zokopha ezigulini ezithintekayo.

I-rhTPO ngokuvamile iyabekezeleka kahle; noma kunjalo, abanye abantu bangase babone imiphumela engathandeki elula njengezinkinga endaweni yokujova, umkhuhlane, noma ubuhlungu bekhanda. Okubalulekile, i-rhTPO ngokuvamile ayibangeli ukwakheka kwezinto ezivikela umzimba ezilwa ne-thrombopoietin yomzimba, okuyinto eyayikhathaza ngama-thrombopoietin mimetics angaphambili. Ukuqapha njalo kuyelulekwa ukuqinisekisa ukuphepha kweziguli ngesikhathi sokwelashwa.

Ukukhethwa kwezifanele zeziguli kubalulekile empumelelweni yokwelashwa kwe-rhTPO. Izinkomba zihlanganisa iziguli ezine-thrombocytopenia ebangelwa ukwelashwa ngamakhemikhali kanye nalezo ezine-ITP engaphenduli ezibonisa ukubala okuncane kwama-platelet. I-rhTPO inikezwa ngomjovo ongaphansi kwesikhumba nge-dosing eyenziwe yaba ngeyomuntu ngamunye ngokusekelwe ekuphenduleni kwama-platelet nesimo sezokwelapha. Abanakekeli bezempilo kufanele balandele iziqondiso ezikhona futhi bacabange ngezinto ezithinta isiguli ngasinye ukuze bathole imiphumela emihle.

I-Recombinant Human Thrombopoietin imele intuthuko ebalulekile ekuphathweni kwe-thrombocytopenia, enikeza ukugqugquzela okuhlosiwe kokukhiqizwa kwamaplatelet ngokusebenza okuhle namazinga okuphepha. Ucwaningo oluqhubekayo luhlose ukwandisa izinkomba zalo nokuthuthukisa amafomula. I-Stellar Biotech Limited, umholi womhlaba wonke kwezixazululo zezempilo, isekela ukuthuthukiswa nokuthengiswa kwemikhiqizo emisha efana ne-rhTPO, ithuthukisa ukunakekelwa kweziguli emhlabeni wonke. Ngeminye imininingwane ngemikhiqizo namasevisi abo aqhakazile, vakashela iwebhusayithi yabo.Imikhiqizo ikhasi noma ufunde mayelana nokuphelele kwabo Insizakalo.